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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) in excess of 27, provided that they also are afflicted by weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and possess at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular physical activity. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% rather than participants who have been given placebos) during a 12- month period, while another study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one year.
Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err on the side of caution and allow the FDA do its job and demand some study be done so that the public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on the medications.
Researchers found that participants taking this drug for any year, lost weight within 4 weeks and have kept the body weight off through the entire 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of several active ingredient, which might make them more potent and safer.
Combo-pilling is the newest fad or in addition to this the newest to come under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular may be the fact that by right now there are not any long term prescription weightloss pills that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA.
Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug may also raise blood pressure level and heart rate, and mustn't be used in those with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.
The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, in addition to by you are not heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.
New UCLA study on smokers with mental, drug, and alcohol problems