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Evidence is increasing that addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in establishing food and sex, plus nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both when they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err to the side of caution and allow the FDA do its job and demand some investigation be done so your public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on his or her medications.

Researchers found that participants using this drug for any year, dropped a few pounds within one month and have kept the body weight off through the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which may make them far better and safer.

Combo-pilling could be the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular is the fact that by right now there are not any long term prescription slimming capsules that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug also can raise blood pressure level and heartrate, and really should not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not be used in patients with uncontrolled high hypertension, and also by you aren't heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.


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