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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided they also experience weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to smoking cessation treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and possess at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes showed that patients had an average weight loss of 4.1% instead of participants who have been given placebos) during a 12- month period, while another study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err assisting caution and permit the FDA do its job and demand some investigation be done so the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on his or her medications.

Researchers found out that participants investing in this drug for the year, lost excess weight within four weeks and have kept the extra weight off through the 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which can make them more efficient and safer.

Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular is the fact that as of right now there are no long term prescription weightloss pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug may also raise blood pressure level and heartbeat, and must not be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

Acamprosate also actively works to eliminate the want to drink by eliminating the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate is just not yet for sale in the United States. While it has become widely studied in Europe the precise chemical reason that it works is still unknown. It is thought that it interferes with receptors within the brain which process glutamate, which in effect alters the way ones body reacts to alcohol intake. Several of the European studies show a lot of promise with Acamprosate in this some of the patients had a nearly double effectiveness for staying sober.


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