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With everything that folks deal with to lose weight, diets that do not work, diet pills that do not do what they are meant to, overpriced exercise equipment, just to name a few. It is no wonder that now the latest idea is to merge prescription medications in the hopes that while using the combination could have the miraculous results that they so desperately want and in some cases need.

Using two separate drugs to shed weight can be very effective you will find combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you need to err on the side of caution and permit the FDA do its job and demand some research be done so your public recognizes the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to make money and that they would say anything to keep people on the medications.

Researchers found that participants taking this drug for the year, lost weight within four weeks and have kept the load off through the 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling may be the newest fad or better yet the newest in the future under scrutiny and so it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug can also raise blood pressure level and heart rate, and really should not be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone will result in instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed inside liver shortly after uptake through the intestines and has no therapeutic effect. Buprenorphine is the active substance; it can be absorbed within the tongue (and throughout the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I also have treated addicts who have had gastric bypass, the location where the first area of the intestine is bypassed and also the stomach contents empty in a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy the place that the drug is taken up through the duodenum and transferred straight to the liver with the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be adopted by servings of the intestine that aren't served by the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.


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