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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight reduction in addition to a reduced-calorie diet and physical exercise.

Using two separate drugs to shed pounds can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you should err to the side of caution and permit the FDA do its job and demand some research be done so that the public recognizes the side effects and hazards of the medications before we take them. Keep in mind that drug companies will be in business to earn money and that they would say everything to keep people on their own medications.

Researchers found out that participants using this drug for the year, dropped a few pounds within a month and have kept the extra weight off through the entire 56 weeks in the study. Contrave is a combination with the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, that might make them more efficient and safer.

Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and thus it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular is the fact that at the time of right now there are not any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure level and heartbeat, and shouldn't be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

"This will be the first drug I'm mindful of that targets both appetite and reward centres within the brain," he said.

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