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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight management in addition to a reduced-calorie diet and physical exercise.

Using two separate drugs to lose weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done so your public knows the side effects and dangers of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say everything to keep people on their own medications.

Researchers found out that participants taking this drug for the year, dropped excess weight within 4 weeks and have kept the weight off throughout the 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more effective and safer.

Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that by right now there are no long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise blood pressure level and heartrate, and really should not be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must 't be used in patients with uncontrolled high hypertension, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.

Approving a drug using this many potentially lethal unwanted effects is inconsistent while using mission statement from the FDA. The power from the drug manufacturing lobby is blatantly evident inside approval of countless drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside the US.


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