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Evidence is increasing that most addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you ought to err on the side of caution and let the FDA do its job and demand some investigation be done so the public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on his or her medications.

Researchers found that participants taking this drug for any year, lost excess weight within a month and have kept the extra weight off through the 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which might be made up of many active ingredient, which can make them more effective and safer.

Combo-pilling is the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that by right now there are not any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise blood pressure and heart rate, and really should not be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.

The most common negative effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.


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