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It was discovered that naltrexone and bupropion combined, which may be marketed in the foreseeable future as Contrave, have better weight loss results than exercise and dieting alone.

Using two separate drugs to lose weight can be very effective you will find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err on the side of caution and allow FDA do its job and demand some study be done so that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their own medications.

Researchers discovered that participants taking this drug for the year, lost excess weight within 4 weeks and have kept the weight off through the entire 56 weeks from the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, that might make them far better and safer.

Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that since right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA.

Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise blood pressure and heartbeat, and mustn't be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high blood pressure levels, in addition to by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.

From a psychiatric viewpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior may be hijacked through the addiction, and malfunctions so that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus as well as the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).


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