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It was found that naltrexone and bupropion combined, that could be marketed down the road as Contrave, provide better weight loss results than diet and exercise alone.

Using two separate drugs to shed pounds can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people who go through it one should err along the side of caution and let the FDA do its job and demand some investigation be done so your public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on the medications.

Researchers found out that participants investing in this drug to get a year, dropped excess weight within a month and have kept the weight off through the 56 weeks from the study. Contrave is really a combination from the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which can make them more efficient and safer.

Combo-pilling is the newest fad or better yet the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that as of right now there are no long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug also can raise blood pressure level and pulse rate, and really should not be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure levels, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients towards the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone will result in instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed inside the liver after that uptake in the intestines and it has no therapeutic effect. Buprenorphine may be the active substance; it is absorbed within the tongue (and during the entire mouth) but destroyed from the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who have had gastric bypass, the location where the first section of the intestine is bypassed and also the stomach contents empty right into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy the location where the drug is taken up with the duodenum and transferred straight to the liver by the portal vein, where it can be quickly and completely destroyed. After gastric bypass naloxone can be used up by servings of the intestine which are not served from the portal system, causing blood amounts of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.


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