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Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug could also raise blood pressure levels and heartbeat, and must not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and pulse rate and must not used in patients with uncontrolled high blood pressure, as well as by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

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