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The FDA announced the approval of an new fat loss drug on Sept. 11, 2014. The drug name is Contrave.

Using two separate drugs to shed weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err to the side of caution and allow FDA do its job and demand some study be done so that the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say almost anything to keep people on their medications.

Researchers found that participants investing in this drug for a year, lost weight within four weeks and have kept the body weight off through the 56 weeks from the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of several active ingredient, that might make them more effective and safer.

Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug can also raise blood pressure level and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high hypertension, in addition to by a person with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed inside liver shortly after uptake in the intestines and has no therapeutic effect. Buprenorphine could be the active substance; it can be absorbed beneath the tongue (and throughout the mouth) but destroyed by the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who've had gastric bypass, the place that the first part of the intestine is bypassed and also the stomach contents empty into a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy in which the drug is taken up with the duodenum and transferred straight away to the liver from the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine that are not served from the portal system, causing blood amounts of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.


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