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Researchers found that participants using this drug for any year, lost excess weight within a month and have kept the extra weight off throughout the 56 weeks from the study. Contrave is really a combination from the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which can be made up of several active ingredient, which can make them more effective and safer.

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Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug could also raise blood pressure and heartrate, and shouldn't be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high hypertension, as well as by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

Other people who should avoid using Contrave are patients experiencing bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave mustn't be prescribed for females who are pregnant or looking to become pregnant.

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