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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) in excess of 27, given that they also suffer from weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that includes a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes showed that patients had an average weight loss of 4.1% instead of participants have been given placebos) within a 12- month period, while another study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to shed pounds can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err on the side of caution and allow the FDA do its job and demand some study be done so your public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to earn money and that they would say anything to keep people on the medications.

Researchers found that participants investing in this drug for any year, dropped a few pounds within 4 weeks and have kept the body weight off during the entire 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which are made up of more than one active ingredient, which may make them more efficient and safer.

Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular is the fact that as of right now there aren't long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise hypertension and pulse rate, and shouldn't be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, as well as by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

To keep up with the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click on the subscribe link at the top of the page to obtain email notification when new submissions are published. Please leave a comment for virtually any article.

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